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Concept paper-Kheti Virasat’s Medicos Workshop
Impact of Pesticides on Health: A critical and in-depth scientific analysis

1. BACKGROUND

Recovering from the euphoria of Green Revolution India is now battling from residual effects of extensively used chemical fertilizers and pesticides.

The decade from 1980 to 1990 alone saw the area under pesticides in India increase a whopping 20-fold, from six million hectare to 125 million hectare. After a high annual consumption of nearly 75 000 MT reached in the early ’90s, interventions in the form of Integrated Pest Management (IPM) practices have only now started to show a declining trend in the use of pesticides in India.

Interestingly, India’s consumption of pesticides per hectare is low when compared with world averages—0.5 kg/ha against Korea’s 6.60 kg/ha and Japan’s 12.0 kg/ha. According to the pesticides industry statistics, India spends $3/ha on pesticides compared with $24/ha spent by Philippines, $255/ha spent by South Korea and $633/ha by Japan.

Yet, despite a comparatively low use of pesticides in India, the contamination of food products in the country is alarming. About 20% of Indian food products contain pesticide residues above tolerance level compared to only 2% globally. No detectable residues are found in only 49% Indian food products compared to 80% globally. "The reason lies in non-judicious use of pesticides, lack of awareness, and inadequate information dissemination amongst the farming community in India," says Dr N Ramesha, research associate, TERI, who is working on a project relating to bioremediation of pesticides contaminated soils in India.

A pesticide is any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest. Pests can be insects, mice and other animals, unwanted plants (weeds), fungi, or microorganisms like bacteria and viruses. Though often misunderstood to refer only to insecticides, the term pesticide also applies to herbicides, fungicides, and various other substances used to control pests.

By their very nature, most pesticides create some risk of harm to humans, animals, or the environment as they are designed to kill or otherwise adversely affect living organisms. At the same time, pesticides are useful because of their ability to kill potential disease-causing organisms and control insects, weeds, and other pests.

Studies show that pesticides can cause health problems, such as birth defects, nerve damage, cancer, and other effects that might occur over a long period of time. World Health Organization (WHO) estimates one million pesticides poisoning cases and 20,000 deaths every year globally.

It is now increasingly believed that many of the environmental problems that have come to light in the past 40 years are not isolated from each other at all but rather have been caused by just one class of chemicals: Organochlorines.

This class includes the notorious DDT, dioxin, HCH (hexachlorocyclohexane), and Aldrin. The production, use, and disposal of Organochlorines create a scary range of problems. While not all Organochlorines have the same impacts, the chemicals as a class include carcinogens, endocrine disruptors, and substances that harm nervous, reproductive, and immune systems. Almost every Organochlorine studied has been linked to some environmental or human health harm.

Organochlorines are carbon-based substances that have one or more chlorine atoms. Many Organochlorines are persistent, lasting in the world for years before degrading. Dioxin is literally forever. Wind and air currents take these chemicals far from their homelands. Organochlorines have been found everywhere, even in areas where the chemicals have never been used.

Unfortunately, 40% of all pesticides used in India belong to the Organochlorine class of chemicals. Another 30% of the pesticides used belong to the organophosphate category. Monocrotophos, phorate, phosphamidon, ethane, methyl parathion and dimethoate are some of the highly hazardous pesticides that are continually and indiscriminately used in India. Most of these chemicals are banned in other countries and the rest are awaiting risk assessment reports before action can be taken.

 

Source: Safety evaluation and monitoring (1999)

While DDT, HCH, Aldrin and endosulfan were banned in the US and many other countries as early as in the ’70s, they are still being used in India. In fact, DDT, HCH (the gamma form) and Malathion account for 70% of the total pesticides consumption in the country. The pesticides banned in India continue to flow into the market despite government notifications. The small farmers prefer them because they are cost-effective, are easily available and display a wide spectrum of bioactivity.

India has become self-sufficient as regards the production of food grains after the Green-revolution with the coordinated efforts of the policy makers the scientists and the farmers of India in general and of Punjab in particular but the aftermath of this exercise was never thought of. Relatively large amount of synthetic chemicals have been introduced and used by farmers during the last four decades, which are posing a potential hazard to human & its environment.

1.1 Hazards Of Pesticides

Adverse effects of pesticides in the environment first received widespread attention in the 1960s.  However, only recently it has been postulated that long term, low exposure of these chemicals are increasingly linked to human health effects such as immuno-suppression, endocrine disruption, reproductive abnormalities and cancer. In industrial setting workers engaged in manufacturing and formulation of pesticides and also rampant use of these chemicals in the agriculture field have resulted in:

  1. Health hazards to men from direct or indirect exposure to pesticides

  2. Development of resistance among pests to pesticides leading to a vicious cycle of use greater dose leading emergence of new resistant species and pest resurgence due to destruction of natural enemies

  3. Pesticides residue in food, water, soil and fodder

  4. Poisoning of wild-life and livestock

  5. Environmental pollution

  6. Ecological imbalance

Pesticide and its impact on Women Health

Clearly pesticides pose health risks for women. In general, most pesticides have not been adequately tested for safety. Pesticide exposure is one of the most widely studied occupational risk factors, with the United Nations Environment Program estimating that accidental pesticide poisoning causes 20,000 deaths and 1 million cases of illness per year worldwide (7). In general, data on pesticide poisoning is notoriously underestimated.

Pesticides have been implicated in human studies with leukemia, lymphoma, aplastic anemia, soft tissue sarcoma and cancers of the breast, brain, prostate, testis and ovaries.. The International Agency for Research on Cancer has found "sufficient" evidence of carcinogenic potentiality in eighteen pesticides and "limited" evidence in additional sixteen pesticides.

Studies have shown a link between a variety of reproductive health impacts in women and pesticide exposure. Studies have documented increased incidence of miscarriages, stillbirths and delayed pregnancy among women agricultural workers and wives of men employed in pesticide mixing and spraying. There is also evidence of increased risk of birth defects from parental exposure to pesticides, although the extent of this risk is uncertain (8). Specific herbicides, such as 2,4-D and 2,4,5-T, disrupt estrogen cycles in women and can cause menstrual-cycle problems in animals. Carbonate and organophosphate insecticides have been reported to increase birth prematurely and spontaneous abortion rates. Other pesticides such as Aldrin, Dieldrin, chlordane and toxaphene can also disrupt reproductive cycle (9). Other recorded health effects from research with women in the field include acute effects such as dizziness, muscular pain, sneezing, itching, skin burns, blisters, difficulty breathing, nausea, nail changing color and sore eyes.

DDT was one of the most widely used chemicals for controlling insect pests on agricultural crops and controlling insects that carry such diseases as malaria and typhus. The presence of DDT in the environment is generally a result of contamination due to past production and use and subsequent movement from sites of application to land, water, and air. Although there is a diminishing trend of DDT use worldwide since the 1970’s a number of countries still use the substance for malaria control. DDT has been proven to cause cancer in laboratory animals, therefore the U.S. Department of Health and Human Services has determined that DDT may reasonably be anticipated to be a carcinogen (10). The analysis of links between breast cancer and pesticides began with Israeli scientists examining the connections between the significant drop in breast cancer that took place between 1976 to 1986 and the policy to ban several Organochlorine insecticides (11). Subsequently researchers have continued to explore the relation between these substances and breast cancer risk, with evidence that xenohormones can cause damage to DNA. There is clearly urgent need for long-term comprehensive study that look at the impacts of these exposures throughout women’s life span (12).

Many studies worldwide have reported the presence of DDT and its metabolites in samples of breast milk. In Delhi, a breast-feeding infant receives 12 times the acceptable limit of DDT and in Brazil 4 times. In Zimbabwe, studies in some regions have found all the samples of breast milk contaminated with DDT. In China for example, most children take DDT from breast milk at level 5 to 10 times higher than internationally accepted maximum, even though these chemicals have not been used or produced in that country since 1983 (13). Low birth weight and premature babies have been found to have higher levels of DDE in their blood compared to normal full term babies. Higher levels of DDT have been found in mothers of premature babies.

2. Outcome Of The Study Conducted By Kheti Virasat In Punjab On Impact Of Pesticides On Human Health

 The excessive use of chemical fertilizer like urea, DPK, NPK, etc and pesticides (insecticides and weedicide) have resulted in the disorders of endocrine glands e.g., thyroid, parathyroid, pituitary, kidneys and adrenals. The incidence of cancer, asthma and diseases of kidney, skin and digestive tract has increased by 20-25% in Punjab. Youngsters at the age of 25-30 are suffering from heart ailments and male infertility. Along-with suffering humanity, the soil is also sick with severe deficiency of micronutrients. Decreasing carbon content of soil has resulted decrease in water & nutrient holding capacity. In addition organisms like bacteria, fungi and earthworms have disappeared. Furthermore, selenium levels in Punjab are very high at toxic level.

The food we eat, the water and milk we drink are contaminated with one or other chemicals. So much so the traces of BHC, endosulphan, DDT & HCH the banned pesticides have been found in the most safe & sacred mother's milk in many cases in Punjab. Due to use of Endosulphan in Punjab as in Kerala, increase in birth of mentally retarded (MR) children.

The Bhatinda example

Kheti Virasat team experienced a very amazing fact during its visit to three villages of Bhatinda district that there is exceptionally high number of cancer patents in these villages. Kheti Virasat team went there to study the farmer’s debt and suicide cases. The team finds that the forced excessive use of pesticides for cotton crops had extremely harmful effect on the region’s environment and health of the people. What kind of devastation these pesticides can cause? Can be gauged from the statistics collected from these villages. The pale faces of the people here are attributed to debt and tension.  Yellowing of teeth and joint-pains are common, thanks to the chloride in the water. But the most startling is the alarming incidence of cancer. In the village Ramanvas, a population of two thousand has already seen 25 cancer-caused deaths with another 15 suffering from cancer. Mandikhurd and Harkishanpura have had six and ten cancer deaths respectively. All these deaths have occurred in the last eight years. Kidney failure has claimed one victim each in each village. There are other two who are suffering from kidney problem. The proportion of diabetes relative to the population is also quite high in these villages. Ramanvas has more than 50 diabetics. The other two villages have 8 to 10 cases each. The number those suffering from breathing and skin disorder are also high. Children with congenital defects, including mental retardation are also quite common. In village Harkishanpura about a dozen such birth have taken place in the last ten years. Mandikhurd has had four such cases in last four years. According to Mrs. Harbans Kaur, the sarpanch of Harkishanpura, the complaints of abortions or abnormal births and jaundice during pregnancy have gone up considerably. The incidence of infertility has also increased. Hypertension and high blood pressure have become common ailments.

The Kerala Experience – Catastrophe of village Padre

The village Padre in Kasaragod district of North Kerala is burning example of far more destructive impacts of pesticides. Due to Ariel spry of Endosulfan, (an Organochlorine pesticide) on cashew trees the whole village faces unimaginable health problems. According to Dr.Mohana Kumar Y S, who has been practicing medicine in the area since 1982, has been perplexed with very high incidence of central nervous system disorders in children of that area. These include cerebral palsy, mental and/or physical retardation, epilepsy and congenital abnormalities like stag horn limbs. In addition an increase in blood and liver cancer, infertility, un-descended testis, miscarriages, menstrual irregularities, skin disorders, asthma, etc were also observed. Psychiatric problems and suicidal tendencies have also been rising. Surprisingly, almost all the ailments are restricted to people below 25 years of age.

The residue limits for the pesticide endosulfan in soil, water and vegetables from Padre village have been breached several times over legitimate/permitted level. Blood samples from residents of Padre were also tested at CSE laboratory and had shown several hundred times endosulfan residues from permit able limit.

The Parallels-Padre and Punjab

The experience of Padre village i.e., destruction caused by endosulfan, is a warning to Punjab where farmers frequently use the same endosulfan. If Padre reached this devastating end with only 15 years of endosulfan spraying, then what is going to happen to Punjab where endosulfan is in use for last 25 years? No study or measures have been undertaken yet on this issue in Punjab.

Pesticide kills even in mother’s womb

Dr. S.G.Kabra, physician at the Indian Institute of Health Management Research in Jaipur, links the malady to pesticide use. Pesticides are known to negate the action of folic acid, vital for neural tube development. Pesticide residues in food can inhibit the intake of folic acid leading to birth of babies with congenital defects. The risk is higher if conceived at the time the Kharif and Rabi crops reach the market, a time when pesticide residue is very high, says Kabra’s study. According to Dr. Kabra, pesticides are the main culprits because they are antagonistic to folic acid, a vitamin that is very important for the development of neural tube i.e., future nervous system including that of brain. Studies have shown that pesticide residue in food can prevent the availability of folic acid leading to birth of babies with neural tube defects.

The Vietnam Experience: killing even after thirty years

Between 1961-1975 of the Vietnam War, massive herbicides or defoliants were used. Ninety thousand metric tons of Agent Orange, White and Blue were sprayed over an area of about 38,000 square kilometers. Agent Orange which was a mixture of 2,4-D & 2,4,5-T, contaminated with the extremely toxic Dioxin, or TCDD made about the 80 percent of the chemicals sprayed.

Studies of the effect of the Agent Orange on herbicide-exposed Vietnamese populations have produced suggestive evidence of an excess of primary liver cancers and other evidence of chronic toxicity. According to studies which related to “an increase in the unfavorable outcomes of pregnancy in North Vietnamese woman whose husbands served in the south and were therefore at least potentially exposed to herbicides compared to fellow villagers whose husband had stayed in the North.” A large number of congenital anomalies were reported. These included deformities of sense organs; Orofacial cleft defects, and conjoined twins. The Vietnamese scientists have reported an increase in chromosome aberrations and sister chromatid exchanges on adults and their children directly exposed to herbicides in Vietnam…The abnormalities reported include chromatid breaks, chromosome breaks, translocations and polyploid cells. The above-mentioned genetic aberrations have been found many years after the chemicals had been sprayed.

The people of Vietnam who were exposed to Agent Orange over 30 years ago are still suffering to this day from high rates of cancer and from frightening birth defects. 2, 4-D has been listed as a hazardous air pollutant in America since 1990 and its levels of use are therefore restricted, 2, 4-D went under review with the Indian government in 1995. The government only passed regulations to make the manufacturing process less toxic, however it kept 2, 4-D legal for use. Exposure to 2, 4-D is known to lead to reproductive problems, including spontaneous abortion and birth defects. Prolonged inhalation may cause coughing, dizziness loss of coordination, stomach ulcers and even death.

It is a matter of grave concern that the same chemical is selling in India under Round-up brand by Monsanto and Punjab is a major market for this.

Pesticides leads to male infertility

French and Argentine researchers produced new evidence showing that exposure to pesticides and solvents could be contributing to falling sperm count and rising levels of male infertility. In a study of 225 men from a productive farming region in Argentina, the scientists could found exposure to insecticides, herbicides and fungicides could limit their ability to have children. “Exposure to pesticides and solvents is significantly associated with threshold sperm values much lower than the considered limits for male fertility”, Dr Luc Multigner of the French research institute INSERM said in a report in Human Reproduction.

Dwindling sperm counts have been a cause of concern since Danish researchers reported in 1992 that sperm counts worldwide were declining. Many experts blame environmental- factors for this decline, as well as an increase in testicular cancer also. Although other factors may also be contributing to their infertility, the scientists said exposure to pesticides and solvents were a factor.

 

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